After a young woman goes missing during Mardi Gras, her friends race to keep her from being hurt by a sadistic, voodoo-cursed, Southern family.
When men on a photo safari stumble into a misanthropic doctor’s remote camp with a wounded comrade, the doctor's restless wife supplements her usual pursuit (voodoo, especially as a way to off her husband) with a new one: seduction. As men lose their hearts (sometimes literally) to the alluring voodoo priestess, she embarks on a killing spree that turns the jungle blood red.
A newlywed couple checks into an old hotel in New Orleans where the wife begins having dreams in which she encounters a sinister group of people who seem to want her for some nefarious purpose. When people around her start dying, she realizes she is not dreaming.
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