Don Champagne is a successful furniture store owner, married to a perfectionist and control-freak wife named Mona. Their seemingly perfect suburban life is disrupted when Mona discovers Don's extramarital affair and blackmails him into maintaining the facade of their perfect life, leading to a series of twists and turns, including murder and deception.
Remy is a medical student who has a flair for making his patients comfortable. His genuine concern for the patients in his charge marks him as a hot prospect in his internship program. Pamela works at a children's book publishing company. The two meet via Pamela's brother, who is also Remy's good friend. They fall in love and get an apartment in the East Village of New York. Soon after, the couple begins to indulge in speed and barbiturates. They become heavily addicted. Remy is thrown out of medical school and Pamela quits her job. Remy soon finds himself in debt with the local dealer, Stutter, who introduces his customer to heroin as a revenge for his late bill. Pamela faces the prospect of getting sober at her brother's clinic, but must leave behind a destitute Remy in order to do it.
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