Penny and Wendy originally are co-workers and best friends until Wendy is promoted. Penny feels that she is getting old and can't compete with Wendy, she leaves Hong Kong, takes snake blood to cleanse herself, and then returns to Hong Kong for revenge.
During the construction of luxury apartment buildings a huge nest of thousands of snakes is discovered. Francis Chang (the boss) refuses to delay the construction and orders to kill all the animals. He is repeated warned by his wife, who had some nightmares concerning him and the snakes. They do not manage to kill all snakes and so they take revenge on the construction workers and Francis Chang. Soon thousands of killer snakes under the lead of a giant Boa invades the building an kill all the new inhabitants. Even a snake master can't stop them.
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