Jessie and Gerald arrive at an isolated lake house for some time away. Gerald restrains Jessie with handcuffs as part of a stranger rape fantasy, but he dies of a heart attack, leaving Jessie handcuffed to the bed. She fights to survive and break free, encountering hallucinations and confronting traumatic childhood memories. Eventually, she escapes and overcomes her fears. Six months later, she starts a foundation for sexual abuse victims. In court, she confronts a serial killer who resembles the man she saw during her ordeal, reclaiming her power and triumphing over her past.
In Cabin Fever: Patient Zero, a group of friends on a bachelor party vacation on a remote island find themselves trapped as a deadly flesh-eating virus starts spreading. As they try to find an escape, they discover a research facility where the virus was created, and now they must fight for their lives against the infected and each other.
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