In a multiverse of parallel universes, Gabriel Yulaw is a rogue ex-cop from an alternate universe who is on a mission to kill all versions of himself in order to gain ultimate power. He travels across different dimensions, taking the life force from his other selves, becoming stronger with each kill. However, there is one version of himself, known as 'The One', who has managed to escape his clutches. Now, Gabriel is determined to eliminate 'The One' and become invincible.
While still out to destroy the evil Umbrella Corporation, Alice joins a group of survivors living in a prison surrounded by infected who also want to relocate to the mysterious but supposedly unharmed safe haven known only as Arcadia. In this fourth Resident Evil movie, the original Alice ambushes the CEO of Umbrella Corporation, Albert Wesker, who injects her with a serum that eliminates her superhuman powers. Alice follows an emergency broadcast to a survivors' safe haven in Alaska and eventually finds a small group of survivors in a maximum security prison. Together, they try to make their way to Arcadia, a cargo tanker traveling along the coast. However, they soon discover that Arcadia is actually a trap set by Umbrella to conduct experiments on survivors. With the help of Chris Redfield, Claire Redfield, and other survivors, Alice battles Wesker and attempts to turn Arcadia into a real safe haven.
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