Harry Burns and Sally Albright share a long car ride from the University of Chicago to NYC. They discuss whether men and women can be friends without sex getting in the way. Over the years, they meet multiple times, discussing their lives, relationships, and faking an orgasm at a diner. Eventually, they have sex but grow apart. However, at a New Year's Eve party, Harry tells Sally he loves her and they get married.
In the 90's, two successful Dominicans living in Buenos Aires face rejection, prejudice and ignorance for being HIV positive.
Don and Nicky journey to the big city one night, and pick up two trashy girls who smoke cigarettes and--even worse--wear eye makeup, so naturally they have sex. The next night Don, newly un-virginized, persuades his girlfriend Betty to have sex with him, too. Soon Don and Nicky discover that they have sores and itching "down there", and Don goes to see the school doctor. He is told that he has syphilis, and to tell Betty and have her get examined. It turns out she has syphilis, too. Can their disease, caused by Don's outrageous behavior--which, as the doctor sternly notes, "is condemned by society"--be successfully treated in time?
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