Set in the 1910s, New Frontier follows the Three Mesquiteers as they pose as Indians to stop a crooked businessman from swindling settlers out of their land. Along the way, they encounter ambushes, horseback chases, and a dam construction project that plays a crucial role in their victory.
Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.
The Pony Express is finished as the Post Office plans to award the mail contract to a stage line. Bill and his father put in a bid for the mail, however there are three bids close together. The officials will run a race to pick the winner, and the Banton Brothers sabotage Bill's stage. Mary still believes in Bill until they try to get rid of him by holding up the regular stage with his well-known horse. Bill needs proof to clear himself and expose the bad guys.
Buffalo Bill Cody battles a gang of outlaws secretly headed by an unscrupulous lawyer.
Bob Langdon, a young Pony Express rider, is given an appointment to West Point, but is forced to leave the academy as the result of political intrigue stirred up by enemies of his friend, General George A. Custer. Bob returns to the west and is made a scout for Custer's 7th Cavalry. At the Battle of Little Big Horn, Custer sends Bob with a message for aid, and Bob becomes the only survivor of the battle.
Ex-Pony Express rider Autry ties to protect his US mail franchise as the Pony Express gives way to stage coach mail and the telegraph. Gene's last film appearance as a singing cowboy.
In a rigged gunfight Tom Blake is forced to shoot a man in self defense and is then hunted for murder. After a long trip fleeing the posse he uses a false name and joins the Pony Express which is just about to commence operatons. Relegated to the most dangerous section of the route, he finds himself fighting the District Manager's scheme to sabotage the inital run. But just then a wanted poster with his picture on it arrives.
A Pony Express rider discovers some mysterious goings-on during the construction of a telegraph line. When a murder is committed, he is blamed for it.
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