Harry Burns and Sally Albright share a long car ride from the University of Chicago to NYC. They discuss whether men and women can be friends without sex getting in the way. Over the years, they meet multiple times, discussing their lives, relationships, and faking an orgasm at a diner. Eventually, they have sex but grow apart. However, at a New Year's Eve party, Harry tells Sally he loves her and they get married.
A man tries to quit smoking but faces various challenges and comedic situations along the way. He encounters a flight, a moving walkway, a stewardess, and experiences the allure of Paris, France. He stays at a hotel and enjoys a picnic. There are implied sexual situations and chapter headings. He also visits Corsica and Stockholm, Sweden. At one point, he gets stuck in an elevator. Throughout the story, there are many scenes involving cigarette smoking and the man's attempts to resist the temptation. The plot also involves an inheritance, a screenplay adapted by the author, a sex maniac, a tobacconist, a visual gag, a private detective, a subway, cigars, an office, a secretary, a Rolls-Royce, an airport, and is based on a novel. In the end, the man successfully quits smoking.
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