In 1956 Chicago, Leonard, a tailor, is forced to treat a wounded mobster and hide a briefcase with incriminating evidence. He orchestrates a plan to uncover the rat in the organization and save himself. Betrayal, deception, and a tragic past drive the story.
American Sicario follows the journey of an American DEA agent who goes undercover to infiltrate a powerful Mexican drug cartel. Faced with betrayals, unexpected twists, and dangerous alliances, he must navigate the treacherous world of drug trafficking while trying to protect his loved ones.
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