Manny, Diego, and Sid set sail on an iceberg when their continent separates. They face sea creatures and battle pirates while exploring a new world. Meanwhile, Manny's over-protectiveness of his teenage daughter causes tension. The group reunites with Sid's family, gets captured by pirates, and plans their escape. They reach an island, steal a ship, and save Manny's family from the pirates. They defeat the pirate leader and find a new home on another continent. The film also follows Scrat's quest for his acorn, leading to the separation of the continents and his discovery of a squirrely paradise.
As the ice age comes to an end, Manny, Sid, and Diego join a group of animals on a journey to higher ground to escape the impending flood. Along the way, Manny discovers that he is not the last woolly mammoth and develops a connection with Ellie, a female mammoth. They face various obstacles, including a tribe of mini-sloths and two sea reptiles from the Mesozoic era. Eventually, they all come together to survive the flood and Manny and Ellie decide to stay together as a herd.
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