American tourists at SpiritQuest Sanctuary, a medicine lodge in Peru, share their thoughts about the traditional medicine ayahuasca, and their motivations for drinking it. Don Howard Lawler, founder of SpiritQuest, describes ayahuasca and its beneficial effects, as do the filmmakers themselves.
Desperate to recover from his depression, Dave travels from his home in British Columbia, Canada to Peru in order to experience the healing effects of the sacred medicine ayahuasca. After Dave spends some time in the country, a Shipibo healer begins to teach him how to work with the medicine more deeply.
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