In I Melt with You, four college friends reunite years later for a weekend of debauchery, indulging in drugs, alcohol, and reckless behavior. As their reunion progresses, buried secrets and regrets come to light, causing their lives to spiral out of control. Guilt, depression, and self-destructive behaviors plague their existences as they struggle to confront their past and contemplate the consequences of their actions.
Two married couples become engulfed in a storm of emotional fury when Doctor Leslie Yates runs into writer Doris Wilding, his old college flame, whom he has not seen in ten years. After reminiscing about their past, Doris and Leslie make a dinner date with their respective spouses. On the eve of the Yates's dinner party, Leslie's wife Helen brings home a magazine article written by Doris, which sparks Leslie's memory of his separation from her.
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