In the Texas panhandle, wealthy and influential rancher Homer Bannon is a widower who tends to ignore the townspeople, in particular, the farmhand, and housekeeper, Alma. Along with his sons, Hud and Lon, Homer decides to sell the cattle in order to prevent the spread of foot-and-mouth disease. While Hud has a few drinks at the local bar, his younger brother discovers that their father has too much integrity and refuses to go along with the fraudulent cattle-selling scheme.
Two cowboys, who are down on their luck, take on various odd jobs to make some pocket money. Along the way, they encounter crooked businessmen, negotiate deals, and get caught up in hilarious situations.
When shifty cattlemen Belknap (Walter Miller) and H.R. Shelby (Gordon Hart) are caught shipping infected animals to Mexico, they frame inspector Gene Autry. Now Autry and his sidekick, Frog Millhouse (Smiley Burnette), must catch the bad guys in the act and set things straight. June Storey co-stars as rancher Martha Wheeler. Autry sings "I'm Gonna Round Up My Blues," "Moonlight on the Ranch House" and "Big Bull Frog."
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