When their caring doctor is framed for murder, a group of psychiatric patients must go on the run to prove his innocence. As they navigate the streets of New York City, they encounter hilarious misadventures and unexpected challenges.
After a professor is crippled in a car accident, he blames his wife for the ordeal and attempts to have her killed using the same means. Now hospitalized with amnesia, she appears to be protected by a tiny voodoo trinket that she still clutches in her hand, which possesses her car and other objects, causing mayhem throughout the city.
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