The Bowery Boys come to the rescue when a corrupt taxi company puts the squeeze on several independent drivers.
Sach just lost his job as an assistant to a private detective, but he wasn't paid. Slip goes with him down to the detective's office to demand payment, but finds the office empty. A woman enters the office and mistakes Slip for the detective and convinces him to take on a case to find her sister after offering a $50 retainer.
Slip (Leo Gorcey), Sach (Huntz Hall), Bobby (Bobby Jordan), Whitey (William Benedict) and Chuck (David Gorcey) unsuccessfully try to sell a dilapidated car to a street cleaner for a fabulous amount, so they can get enough money to save Louie's (Bernard Gorcey) Malt Shop. Sidewalk photographer Cathy Smith (Teala Loring) snaps a pictures of three bank robbers as they are fleeing a robbery but when the Bowery Boys and Cathy realize that Sach is also in the photograph, they break into the photo lab to destroy the negative, which might make the police think Sach was involved in the robbery.
Slip and Sach's boss, David J. Thurston, has allegedly committed suicide. Slip finds a book of matches with the name of a local nightclub on his boss' desk and finds out from Gabe that a gambling casino is being run out of it. Slip comes to the conclusion that the club had something to do with his boss' death and sets out to find his murderer. The boys get jobs at the club and Louie poses as a rich cattlemen as they gather the information to convict the murderers.
A ghost helps the Bowery Boys capture a gang of crooks led by a mad doctor.
The Bowery Boys head west to clear Louie of an old murder charge that he had killed his gold-mine partner. Sach has the map to the gold mine painted on his back, and Blackjack McCoy has him kidnapped by Indian Joe. Gabe poses as a dangerous gunman, the Klondike Kid, while Slip is in charge of all the remaining loose ends.
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