In Panamá City, a man stalks a well-to-do adolescent, without knowing that she is the daughter he procreated when he raped a woman.
Former UNIT luminary Liz Shaw and her assistant Bayliss are investigating a series of bizarre murders, all committed near a soon-to-be-closed psychiatric hospital. When the hospital is unexpectedly reprieved by rich Industrialist Peter Russell events seem to move out of Liz's control. Are the incumbent director of the clinic, Doctor Dove and his predecessor Doctor O'Kane harboring the killer? What is the centuries-old horror hidden in the grounds? And what exactly is the secret of room zero?
In 1975, the British Government quietly closed down a secret evolutionary project codenamed BEAGLE, ordering the destruction of all research materials. Today, the horrific discovery of several oddly mutated bodies alerts Liz Shaw and P.R.O.B.E. to the fact that something is stalking the original site of project BEAGLE – something which may challenge the very nature of humanity itself! With a crack security team at her disposal, Liz desperately attempts to track down the perverted results of the project. But who or what is hunting whom?
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