Florence Foster Jenkins, a wealthy New York City heiress, has a dream of becoming an opera singer. She hires a vocal coach and starts performing in front of audiences, unaware of her complete lack of singing talent. With the support of her husband and loyal friends, Florence pursues her passion and becomes famous for her unique performances. However, her delusions and chronic disease eventually catch up with her.
Theater manager James Guthrie's (Melvyn Douglas) career depends on famed soprano Elsa Terry (Grace Moore) singing in his Buenos Aires opera house, however, Elsa breaks the contract in favor of a more lucrative deal in Paris. Desperate, James begins showering her with flowers and candy in an attempt to woo her to the Argentinian opera house. When Elsa overhears James confess to his friend Pancho that he'd be willing to resort to kidnapping to get Elsa to Argentina, she mistakenly believes his motives to be solely romantic.
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