TONIKAWA: Over the Moon for You is a romantic comedy TV show that follows the story of a young man named Nasa Yuzaki, who falls in love at first sight with a girl named Tsukasa Tsukuyomi. After a series of unexpected events, Nasa marries Tsukasa and they begin their newlywed life together. The show explores their unique relationship and the challenges they face as they navigate the ups and downs of married life.

A shy and awkward high school boy, Junichi Hashiba, finally musters up the courage to ask his crush, Yukana Yame, to be his girlfriend. To his surprise, she agrees. However, Junichi quickly realizes that dating a gal, a fashionable and assertive girl, comes with its challenges and expectations.

The series is centered on three friends who are all rookie voice actresses; Futaba Ichinose, Ichigo Moesaki and Rin Kohana. As the girls go through their individual troubles of working in voice acting, they end up hosting a web radio show together and form the unit, Earphones.

When Tsukasa Yuzaki receives a brand new smartphone as a surprise gift from her husband Nasa, she is delighted, quickly adding in contacts and mastering the arts of LINE and sticker-sending. However, her joy is short-lived: a former coworker calls in Nasa for a difficult job, and Tsukasa is dismayed to learn that her beloved might have to work through the night. Faced with her first night alone since her marriage to Nasa, will Tsukasa and her new phone be able to overcome the distance that separates the young couple and defeat the loneliness that threatens to pull her under?

A spur-of-the-moment quiz contest wager leads to a cosplay experiment that spices things up between Tsukasa and Nasa.