A MBBS student attempts suicide by cutting his hand after performing badly at college,. Things take a turn when his blood spills on a tomb of Pottu, and a mysterious power enters his body which forces him to behave like a girl.

Lovers murdered by a moneylender come back as ghosts to make him answer for his crime. Meanwhile, an evil tantric has been waiting for them for years to take his revenge.

An efficient police officer and his son’s lives are gravely impacted when the former is appointed to investigate the mysteries surrounding a palace that's believed to be haunted by the spirit of a former queen. Will they be able to get to the bottom of it all and also manage to safeguard each other from trouble?

Thambi Vettothi Sundaram movie deals with an off-beat subject based on a true story happened in Kanyakumari. It is based on the life of a person in a place that is on the Tamilnadu - Kerala border.