After discourse with Eduardo leads to Edd getting hit by a radioactive blast, Edd gains superpowers and becomes PowerEdd. But Eduardo, as Numero Uno, has other plans.

In the year 2102, a deadly epidemic has wiped out most of humanity. A group of scientists embark on a mission to find a cure, but they soon discover a dark secret that threatens their survival.

When Edd, Tom, and Matt visit a museum, Edd discovers a Old West diary by one of his ancestors, a detective named Edward Gold.

In the very near future, a small group of programmers run the first human trial of DreamStream - a dream writing device deemed the final frontier of entertainment.

Eddsworld is about a guy named Edd that is constantly getting himself into weird situations and hi jinks that require a puny attitude and a great "edducation". (Puns are Edd's thing.)