In the city of Amsterdam, a veterinarian finds himself hunted by a vicious lion that has escaped from the zoo. As he tries to survive, he encounters various obstacles and uses his wit and resourcefulness to outsmart the predator. With the help of a dog and a few unlikely allies, he must navigate the city's streets and landmarks to stay alive.

Handsome, clever final year law student Koen avoids being beaten up by street thugs by claiming he's a maternal cousin of crime baron Henk de Koning. The next day, 'uncle' Henk praises Koen's wit and commandeers his 'cousin's' help to retrieve the treasure presumably hidden by disloyal accomplice Sjon de Nooyer, who was released from jail to a retirement home, by volunteering as an orderly, posing as Sjon's distant relative. Dirty police detective Uitenhaage is after the same fortune, and leans independently on innocent Koen to spy on Sjon.

Vagabond Bob finds a suitcase belonging to stockbroker Peter and returns it to his hotel. There he meets Marion, who happens to be Peter's mistress. Unfortunately in doing so he loses his only possession of value: a lottery ticket.