Set in 1978 Santiago, Chile, Tony Manero tells the story of Raul Peralta, a sociopath who becomes obsessed with impersonating Tony Manero, the character from Saturday Night Fever. As Raul dives deeper into his obsession, he becomes willing to commit murder to achieve his dreams of becoming the ultimate Tony Manero.

Ten years after her daughter was the victim of a hate crime, brutally beaten in the streets of Santiago for being a lesbian, Nancy is asked to participate in an unsolved mysteries TV show that will recreate the incident. Nancy, a hairdresser who has worked very hard to move on with her life, will have to decide if finding justice for her deceased daughter is worth exposing herself and her family on television.

In the winter of 1978, under Chile's military regime in Santiago, Raúl Peralta, a lonely and disabled architectural model maker, lives a quiet life with only his ailing mother and a pet canary for company. His routine is upended by the arrival of new neighbors whose sinister activities seem to conceal dark secrets. Desperately clinging to the last remnants of his sanity, Raúl's life increasingly intertwines with Guillermo, a mysterious man in dark glasses. As reality unravels, the echoes of Raúl's past collide with the horrors of his present in a psychological thriller that leaves behind deep, indelible scars.

18-year-old Rodrigo is arrested by the police in a televised raid on the club where he works as a drag queen.

After long decades of exile, a leftist former activist returns to Chile to settle accounts with his conscience, related to the death of a colleague and political hero . The task of Atalibar is to reveal his secret. But his view clashes with the current country, godless, far from the old ideologies and where all his old colleagues have changed.

Through illustrations and sounds, Una vez la noche experiments with the obsessive narration of four diverse characters –all of which are lost in the settings of their memory– to exhibit crucial events that marked their lives forever. Through a particular mise-en-scène, the film provides apparently ordinary people with a brilliant singularity, introducing us to a new perception of reality.