My Brother, My Sister follows the story of an estranged brother and sister who are reunited after their mother's sudden death. As they navigate their complicated relationship, they discover the true meaning of family and the importance of forgiveness. Set in Rome, Italy, the film explores themes of friendship, life, and the emotional journey of facing past traumas.

Francesco, Carlo, Loco e Giordano, lifelong friends, depart from Rome towards Madrid to celebrate the bachelor party of Francesco but above all to make, as happened on other occasions, a trip together. In fact, the trip is also an excuse to go see their favorite team away in the Champions League. In their path intersect to Pilar, a beautiful Spanish singer who, unknowingly, brings havoc within a close-knit group favoring, including unexpected, laughter and comical situations, even the come to diversity afloat, insecurities and never those words. On their return, nothing will be as before.