Zerophilia is a comedy romance movie that follows a college student who discovers that they have a rare genetic condition called zerophilia, which causes them to change sex. The movie explores themes of sexual identity, transformation, and self-discovery within a comedic and romantic context. With its unique plot and witty humor, Zerophilia takes the audience on a hilarious and thought-provoking journey of acceptance and understanding.

Two young men who have been friends since early childhood decide to go on a trip to find a third friend who has long since disappeared. Stories they have heard indicate that the friend has been seen in an apparently rambling, incoherent state at Coney Island. Their trip leads them to a number of adventures involving the otherworld-like life at the Park and revelations related to their own pasts including the death of one's sister, a failed past relationship, financial failings, and alcoholism.