The people of a crowded colony in Coimbatore city go through a hard time as a few heavily armed criminals enter the place when they try to escape from the cops.

A young man whose constant yawning leaves him out of work gets a gangster arrested by accident. Now, the latter is out to get his revenge, but what he doesn't know is how powerful a yawn can be.

Tamizhuku En Ondrai Azhuthavum is a comedy sci-fi thriller that revolves around love and a bomb. The story follows a group of people whose lives intersect due to an unexpected bomb threat in the city. As they navigate through the chaos, they discover love, friendship, and the importance of making every moment count.