A leading psychologist's much younger wife begins an extramarital affair with his close friend. When the doctor finds out, he plots revenge, which puts himself, his wife, his close friend and his brother in mortal danger.

Puli is action oriented movie in which, Kranthi (Chiranjeevi), an honest police officer who is deputed to the special branch. He has a sister named Lakshmi. Inspector Syam is a corrupt officer and works for Smuggler JK . One day,Syam causes an accident and as a result of which Radha, Kranthi’s fiancee, loses her eye sight and her brother gets killed in the accident. Kranthi goes on hunt and catches corrupt inspector Syam and his associate James. meanwhile, JK Kidnaps Radha and Lakshmi. Rest of the movie is all about how all ends well.