What happens when a guy falls in love with the girl he thought he hated the most? Why does her simple `no` mean so much more than it seems?.

S. Muthu (aka Smoothu) , who is a pickpocket expert, meets with an accident and after that incident, he starts to suffer from a disease, alien hand syndrome, which means that his left hand wouldn't be under his control. Now, what problems this syndrome creates and how does it bring about a change in Smuthu's life?