The series tells the story of two fifteen-year-old twin brothers, Pedro and Bianca, being white and black, which made them known in the region where they live. Pedro & Bianca shows the class C teenagers who recently entered the first year of high school, at the Piquerobi State School (Alberto Torres State School), a public school in São Paulo, and follows the daily lives of both at school, where they face common problems that teenagers experience.

Sixteen-year-old Lola has been stuck in her room for three days; she confesses to a camcorder the secret keeping her locked inside.