American Dad! is a sitcom that revolves around the Smith family. Stan Smith, a CIA agent, is constantly fighting terrorists and upholding American ideals, but also deals with the challenges of being a husband and father. His wife, Francine, is a ditzy yet loving woman who supports her husband wholeheartedly. Their children, Steve and Hayley, are typical teenagers dealing with school, relationships, and their own unique interests. The family is also accompanied by Roger, a sarcastic and unpredictable alien, and Klaus, a talking goldfish with the brain of a German Olympic ski jumper. Together, they navigate through hilarious adventures and satirical social commentary.

The American Dad short film, which preceded the theatrical run of the 2005 feature Fever Pitch, is about Stan Smith touring his work days in the CIA and his "normal" everyday life.