Rome is shattered by a series of gruesome murders that paint the Eternal City deep red. The suspicion grows that these atrocious crimes are connected with the return of one of the most heinous serial killers of our time - Karl the Butcher.

Symphony in Blood Red is an Italian 'giallo', a horror film inspired by the work of Dario Argento. It is the first feature movie directed by Luigi Pastore, and in collaboration with Antonio Tentori (Cat In The Brain), who co-wrote the screenplay.

A famous Italian-American writer of horror novels goes to Italy to spend a few days in an old house on the coast. The history of the house begins to manifest itself with hallucinations, which the writer notes as ideas for his novel. He then meets some locals who tell him the story of a cult who came to the house in the 1970s to build a temple dedicated to Satan.