Kawauchi Miyabi was once a promising neurosurgeon, but an accident caused damage to Miyabi's brain. She is unable to remember the past 2 years of her life and she will forget everything that happened today when she wakes up the next day. She has all but given up on becoming a doctor and works as an assistant nurse. One day, Neurosurgeon Sanpei Tomoharu appears in front of her. He is known as an eccentric person. Sanpei Tomoharu guides Kawauchi Miyabi at his own pace, regardless of her will. This actually helps Kawauchi Miyabi as a doctor and a patient. The mystery hidden in her missing memories is gradually revealed, which contains a secret.

Haruno Shotaro and his girlfriend Mimori Arisa get into a car accident. The next moment, when he wakes up, he finds out that he is in the hospital and has a cast on his right foot and left hand. Soon, Haruno Shotaro thinks that something is really strange with the hospital. The hospital has weird patients and the doctors and nurses seem to be hiding something. A mysterious serial murder case also takes place outside the hospital. What is the connection between the hospital and the serial murder case? What is happening in the hospital?

Donoue General Hospital runs into a budget deficit, even though the doctors drive expensive imported cars and live an outlandish lifestyle. Office manager Momoi finds surgeon Kosuke Sagara through a medical website. Kosuke Sagara arrives at the hospital and tells the director of the general hospital to decide on his pay after watching his work. Kosuke Sagara informs the hospital that he had previously quit his job at a university hospital and taken a year sabbatical.

The body of a young woman is discovered in a park in Tokyo with all her organs removed. The case is assigned to Detective Inukai, a usually cool and unemotional detective known for seeing through the lies of others. But Inukai has a young daughter in need of a kidney transplant, so when the first crime is followed by two similar crimes, Inukai is caught between his roles as a detective and a father.

A corpse of a clown is found in a park. Detective Shirataka Amane of Musashino Higashi Police Station begins investigating with rookie detective Uzuka Shinsaku. They find a picture of the victim holding a balloon with the number 1 and the letters TTX on social media which indicates pufferfish poisoning. Shirataka intuitively suspects that this is an incriminating statement done by a serial killer, but Chief Investigator Fukukawa Saeko denies her. Detective Kusano Seiya and other personnel of MPD First Investigative Division join the investigation, then a second murder occurs. Shirataka recalls an unsolved kidnapping and murder case from two years ago that she still regrets.

Surgeon Sagara Kosuke changed the mentalities of the doctors and nurses at Dogami General Hospital with a mixture of severity and cajoling. Before that, the hospital appeared to be a hopeless case. All the director Dogami Tamaki and administrator Momoi Shoichi thought of was its finances while the doctors did not care about patients. But Sagara is not the typical medical hero who is a stifling, hot-blooded, good person. He would stop at nothing to improve the hospital for patients and adjust his strategies according to the challenges and parties involved. Now the problem of the hospital’s next successor rapidly surfaces and intensifies the antagonism between Sagara and Moriyama Takashi.

『DOCTORS』is back! Played by Sawamura Ikki, Surgeon Daisuke Sagara is back again during the new year of 2021. Masanobu Takashima, the director of the group, is preparing for the 100th anniversary of his Dojo General Hospital. However, the management condition of the deficit continued...Reiko hanamura, who was in charge of the loan section, was hospitalized at the hospital...

Hana, 21-year old, is sent to a mental hospital for attempting a suicide. She suffers from hearing a deep male voice in her head almost everyday that goes, "Twenty yards of linen are worth one coat..." She gradually regains her peace of mind by traveling across Kyushu dragging with her Nagoyan, a guy from Nagoya who is suffering from depression. They take on their journey on Nagoyan's old faithful car, Luce.