Rawhide, Arizona, was certainly some tough town when Reverend Simpson first blew in from civilization and started his campaign of redemption. From Alkali Ike to Shorty Smith, not a man of them had seen the inside of a church in fourteen years; there has never been a sermon preached in the county, and the only hymns that had ever been heard were those of the coyotes. The Rev. Simpson soon set up the "Rawhide Mission," but in spite of the hot weather, the result was a heavy frost. Nobody came even as far as the door, except Black Mike, who was drunk and who thought he was at the XXX saloon. The worthy pastor pleaded, prayed and billed the town without result.

As a baby, John Ermine is stolen from a wagon train by the Crow Indians and is adopted by Chief Fire Bear. John grows to manhood, ignorant that he is a white man until his parentage is disclosed to him by Crooked Bear, a white hermit who is on friendly terms with the Crows. Crooked Bear teaches John the language and customs of the white man's civilization, impressing upon him that it is his sacred responsibility to keep peace between the white men and the Indians.

Arizona range rider Lon Gilchrist helps stagecoach passengers fight off attacking Apaches. After rescuing a baby and binding her bleeding forehead with his handkerchief, Lon receives a reward that allows him to buy a ranch. Many years later, the rescued child, Lizzie Mayberry, is a waitress in a cheap restaurant, where she meets Lon, who, now wealthy, courts and marries her. Because he is so busy, Lon has his friend Del Beasley look after her. After a misunderstanding, Lizzie has Del take her to the railway station. Thinking that they left together, Lon pursues them.