In 'Big Monster on Campus,' a socially awkward high school student performs a scientific experiment to impress his classmates. However, things take a dark turn when the experiment goes awry and transforms him into a monstrous creature. As he struggles to hide his new identity and deal with the consequences, chaos ensues in the form of house parties, serial killers, and Halloween madness.

A scientist and his young daughter are taken hostage by a group of terrorists inside a power plant in Old Mexico. One of the terrorists happens to have captured the legendary "El Chupacabra" and set it loose in the power plant.