Ten years have passed since the alien war, and now the line between human and alien is blurred. The film follows two vagrants who were once subjects of a dangerous experiment involving the assimilation of alien and human DNA.

After the fall of EonCorp, efforts to dispose of all remaining alien biotech are made in vain as new aberrations emerge in the streets, beyond anyone's control...

The lethal alien virus known as ‘Havoc’ has spread beyond the South Mill District, and into the rural outreaches. An infected boy wanders the ravaged region, finding necrotic remains and mutant creatures along the way, as the Havoc virus begins to evolve to the next level of alien horror in this sequel to 2018’s ‘South Mill District.