De Luizenmoeder is a hilarious comedy series that revolves around a single mother who finds herself in the unexpected role of dealing with head lice in an elementary school. She navigates through the challenges of the school environment, including quirky teachers, judgmental parents, and mischievous students, all while trying to balance her personal life.

Two families join forces for a sailing holiday, but after their navigation equipment stops working, they find themselves stranded on a mysterious island that doesn't seem to exist on any maps. But they are not alone.