My Brilliant Friend is a TV show that tells the story of the friendship between two girls in love in the impoverished neighborhoods of Naples. Set in the 1950s and 1960s, the show explores themes of violence, coming of age, and the struggles of teenage girls in love. It also highlights the vibrant atmosphere of Naples, with its shoe shops, seaside, and firework-filled weddings.

It follows Francesco Giuffrida, an honest Sicilian politician from childhood to his disappearance.

Mia and Ele share an important journey that will make them face their ghosts and grow up. A journey through amazing or run-down Italian scenarios, from the South to the North, discovering places, but above all discovering themselves.