Night and Day is a 1946 American musical romance drama film inspired by the life of songwriter Cole Porter. The film chronicles Porter's struggles with depression, his turbulent relationships, and his rise to fame in the world of popular music. It explores themes of love, loss, and personal growth, as well as the power of music to heal and inspire.

J. D. Forbes, head of the almost-bankrupt Four Star Studios in Hollywood contacts band leader Kay Kyser, who puts on a radio and-live theatre program called "The Kollege of Musical Knowledge," to appear in films. When manager Chuck Deems gets the studio offer, he and band members Ginny Simms, Sully Mason, Ish Kabiddle, Harry Babbitt and the others are all fired up at the prospect of going to Hollywood and working in the movies, but band-leader Kay is all against it and says his old grandmother has told him to stay in his own back yard, but he relents. Once there, Stacey Delmore, a Four Star associate producer left in charge of the studio while Forbes is out of town, discovers that the screenplay writers have prepared a script that has Kay Kyser playing a glamorous lover in an exotic European setting.

National DJs help a promoter make an unknown girl a star, to prove the power of radio over TV.

Hedda Hopper guides us through some of Hollywood's sights; the home of William S. Hart and a Kay Kyser recording-session being among them.

A group of people attend a radio quiz show at a spooky mansion, where they encounter strange occurrences and try to uncover the truth.

In this slapstick comedy, Abbott and Costello find themselves in a series of hilarious situations as they try to hit the ice. From trick skis to a Murphy bed chase, their comedic antics keep everyone laughing.

Lulu Monahan, the press agent for John Barrymore, is attempting to get a sponsor for a radio program. To that end, she and the agent for bandleader Kay Kyser, plant a story that the great Shakespearean actor, over his heartfelt objections, will teach Kyser how to play Shakespeare, which isn't the same as playing Paducah, which soon becomes evident.

Broadway producer Johnny Demming is only interested in big-name talent and scoffs that his sister, father and other small-time talent could be used in a successful show.

Soldier Johnny Grey is engaged to marry singer Mapy Cortes, but his plans go awry when he learns that he is the heir to $100,000 from his great-grandfather -- a bequest that comes with a catch: before claiming the money, Johnny must marry a descendant of his great-grandfather's Civil War enemy, General Havelock-Allen. Not wanting to disrupt his planned marriage to Mapy, Johnny must figure out how to concoct a temporary marriage-of-convenience with the descendant -- who turns out to be the beautiful Terry Havelock-Allen.

It's Fibber and Molly's 20th anniversary and they want to throw a big party. But when everyone declines their invitation, they decide to go on a second honeymoon instead. After one night at the broken down Ramble Inn, where they spent their first honeymoon, they decide to go across the lake to a swanky (and expensive) lodge, where they bump into their old friends Edgar Bergan, Charlie McCarthy, Gildersleeve, and Mrs. Uppington, so the party is on again.

A crook becomes the victim of a crafty card player who works for the District Attorney.