My Brother, My Sister follows the story of an estranged brother and sister who are reunited after their mother's sudden death. As they navigate their complicated relationship, they discover the true meaning of family and the importance of forgiveness. Set in Rome, Italy, the film explores themes of friendship, life, and the emotional journey of facing past traumas.

Ninni and his father Amelio wish to redeem their modest lifestyle. An opportunity will arise when the father, who works as an Elvis lookalike, is called to perform in a rich seaside resort. On that night, however, Ninni will be forced to come to terms with the harsh reality of the real world.

The story of a young student in the South of Italy, his trip during the night, by feet, from the native village to the City, a long coming-to-age itinerary that will lead him to discover his familiy's secret story and free him from fears.

The psychiatrist Anna go on holiday with her daughter to the South of Italy where her father lives. Anna meets an old lawyer friend who asks her to run a psychiatric examination on a man who killed in a moment of homicidal madness.