Escrava Isaura is a dramatic and romantic TV show that takes place in 19th century Brazil, revolving around the life of a beautiful slave named Isaura. Despite facing constant hardships, Isaura's spirit remains unbroken. The story delves into her struggles, love interests, and her ultimate fight for freedom.

To defend the humble Soró Sereno in a traffic accident, the mysterious Ciro Cerqueira, a bus driver, ends up getting involved with the traditional italian family of Mamma Vittoria Cantarelli, owner of a chain of canteens in which he starts to work as an executive, and is torn between the love of the matriarch's granddaughters, the responsible Luísa and the seductive Bruna, a woman who spares no effort to get what she wants.

After suffering a plane crash, Leo receives a blood transfusion and, some time later, discovers that he ended up contracting the AIDS virus. Desperate, he does his best to find out the identity of the bearer of the blood he received, and suffers from the prejudice of friends and people close to him.

Iolanda, a widow who is the matriarch of a large and complicated family, is the hostess of a large party in a mansion that brings back many memories. The celebration is marked by a barbecue with lots of gossip and fun among old friends.