In the Strange Pursuit of Laura Durand is a thrilling action comedy that tells the story of a desperate man who embarks on a quest to find Laura Durand. Faced with various obstacles and challenges, he must navigate through a world filled with mystery and danger to uncover the truth. Along the way, he encounters hilarious situations and unexpected twists that keep the audience on the edge of their seats.

A real estate agent who is interested in investing wanders around the area of Neos Kosmos in Athens, formerly known as Dourgouti. Through his eyes unfolds the past, present, and uncertain future of this once degraded district. A district resembling a deserted island, right next to Acropolis, following the fate of similar areas around the globe.

Maria and Loukas decide at the same time and for no apparent reason to respectively run away from their homes. Each of them has to deal with their personal problems: Maria is stuck in a wealthy marriage with Dimitris while raising their two children. Loukas is unemployed and full of debts. Both of them run away from their personal issues, both of them begin wandering in modern day Athens. They come across a series of controversial events and meet with strange characters. Furthermore, various people seem to be on their track; Maria is followed by two policemen. Loukas is followed by a weird stranger dressed in black, Joseph, who desperately wants something from him.

Antonis lives alone in his family's beach house, hiding away from the world. He has given up on life and is literally watching the world pass him by. It has been left up to his best friends - two offbeat cupids - to remind him that there are things to live for.