In 1973, a young boy grows up in Long Island, navigating relationships with his deadbeat father, his college-graduate mother, and his eccentric extended family. Seeking guidance and a sense of belonging, he finds solace in the local bar and forms a bond with its bartender, who becomes a father figure to him. As he struggles to find his place in the world, he becomes more and more determined to break free from the limitations of his upbringing and pursue his dreams of becoming a writer.

"Nothing Will Be the Same Again" is an urban "Stand By Me" crossed with the Little Rascals. Eleven-year-old Marty and Miguel are best friends in 1964 Brooklyn. When Miguel is killed, Marty is forced to grow up.