The Venture Bros. follows the lives and misadventures of the Venture family, consisting of two bumbling brothers, their scientist father, bodyguard, and various villains and heroes they encounter. With a mix of action, comedy, and parody, the show explores themes of family relationships, villainy, and the consequences of failure.

Doc's latest invention has the potential to either lead the Ventures to bankruptcy or propel them to new heights. They must navigate the risks and rewards that come with it.