Doctor Doctor follows the story of a talented and arrogant heart surgeon, Hugh Knight, who is forced to work as a local doctor in his small hometown in Australia after a scandal. As he navigates the challenges of small-town life, he discovers the true meaning of community and redemption.

After experiencing a tragedy involving his teenage daughter, a psychotherapist named Peter Bower starts seeing deceased individuals from his past. As he delves deeper into his patients' problems, he realizes there is a supernatural element connecting their traumas and his own experience. Peter must confront his own past and uncover the truth about the mysterious events before it consumes him.

Running the remote Hope Island Clinic, Sam Stewart is an accomplished doctor, who with her team, looks after the residents of all the neighbouring islands, as well as the holidaymakers and thrill seekers who visit the area. Not only a GP, Sam is a single mother with a free spirit and a determination – who has an unusual hobby: venom.

In the midst of a global epidemic, Annie finds herself the sole carer of her eight-year-old nephew, but he has questions only a mother can answer.

Aishe sees her father kiss his new love for the first time since her mother's death. Unable to sleep she wakes up her younger sister for company.