After being hit by a car, Samantha wakes up from a coma with retrograde amnesia. She must learn who she was before the accident and navigate her relationships, career, and personal life. Along the way, she discovers shocking secrets and questions the identity she had before the accident.

After a young girl witnesses her father having an affair, she declares she will never love anybody ever again. As a result, her guardian angel is forced to abandon her. Later, when she grows to be a miserable woman, her angel is given a second chance to save her from a life of sadness. To accomplish his goal, he travels through time to recruit the woman's past and future selves to help her reconcile with her father and change her direction in life.

In Dublin, Blake Lester breaks Lucy Silchester's dream by preferring an overseas TV show career move over their marriage plans since years. Receiving a mystery letter 'from her life', Lucy seeks consolation with mates Adam, Melanie, Lisa and Jamie. Angrily Lucy meets critical sender Cosmo, who urges her to set priorities among colleagues, family, friends and truth to correct her derailed life, which she finds hard to disprove by showing happiness. Lying to boss Edna costs her job. Desperate hitting rock bottom, she attempt to win successful Blake back. Her protective brother, attorney Riley, and Cosmo rather favor attractive carpet cleaner and neighborhood urchins football 'coach' Don Lockwood, who consents, yet this fails as she retracts despite good sex while he works in her apartment. Sad news about her neighbor Claire, a breakup between workaholic father Samuel and 'neglected' mother-housewife Sheila make Lucy die reconsider her own priorities.