While on tour through Latin America, los Grandes del Buen Humor are confused with volunteers for a space travel and get tangled with spies.

A woman helps a scientist who deliberately infects himself to test the efficacy of a vaccine.

A priest is unjustly sentenced to death for a murder he did not commit. The surprise will be greater when he, while in prison, knows who the murderer is through the confession of his daughter.

In their purpose of going to Hollywood ¨Los Cinco Grandes del Buen Humor" are going to stop in Texas.