In the romantic comedy Hart op de juiste plek, we see how the young and successful Eve (Stijn Fransen) lives her dream life. A cool job as a freelance trend watcher, a nice group of friends and living together with her handsome boyfriend Ricardo (Jasper Demollin) in the big city.

During the annual family weekend in theme park "De Efteling", eleven-year-old Teun discovers that his recently deceased grandfather left him one last scavenger hunt inside the park.

Pleun from Rotterdam has been running Casa Coco, a guest house for reflection and rest on Bonaire, for years. The Rotterdam people from her own circle of acquaintances like to come over for a wonderful holiday together. This autumn, Pleun's childhood sweetheart Toon comes along with a befriended couple after his wife announces she wants to divorce him, to make him forget his problems under the Antillean sun. The two ex-lovers have not seen each other for years. Because Pleun left Toon out of the blue fifty years ago and went to Bonaire, Toon falls back from one problem to another.

After the death of his wife, pig farmer Ronald is responsible for the care of their daughter and the farm. The ever stricter environmental requirements hang around his neck like a millstone. When, to make matters worse, animal activist Erik, unaware of Ronald's situation, starts an ever stronger hate campaign against him, Ronald is desperate.