Lukka Chuppi delves into the lives of a group of married couples, where the husbands are close friends. The story shows the group getting together after 14 years. The wives see a new side to their husbands suddenly, singing and laughing like how they were during their college days.

Two immigrant families, residing in the same building complex in Dubai, find themselves in conflict due to misunderstandings. However, things take a wild turn when the true culprits behind the love affairs are revealed.

The movie depicts the life of a tribal youth named Prakasan who lives with his mother and sister in Chamakundy, Kerala. He dreams of having a job in a city, which comes true. Prakasan's designated job is a health care worker which includes locating prostitutes to distribute condoms and spread awareness. He finds it hard to wrap his head around this in a fast-paced life.