Goutham is a young businessman who lives with his mother and grandmother. Goutham's mother Vasundara Devi is the head of their family business. Vasundara Devi is a strict mother; but grand motheris extremely friendly with Goutham. Apporva is Goutham's best pal. Then enters Nithya, a sand animation artist. Goutham meets Nithya and after a series of incidents, the couple falls in love. But Nithya, who has a memory loss problem due to a major accident,can't remember anything more than a day. This problem creates obstacles in Goutham and Nithya's relationship and this forms the crux of the story.

Manoharam is a comedy-drama film about a struggling artist named Manoharan who tries to make a living through his art. Despite facing numerous challenges and setbacks, he finally finds fame and success in unexpected ways.