The Heiresses follows the story of a lesbian couple in Paraguay who used to be wealthy but are now facing financial hardships. They have to cope with their deteriorating lifestyle by selling off their inherited possessions. As they try to navigate through their new reality, they face various challenges and make sacrifices in order to survive.

A group of students of the environmental engineering career go to the neighborhood of the Monday River to do a job, during the night they hear a scream, Viviana (the protagonist) witnesses a moment that will unleash an overwhelming situation in her life that will guide her At the origin of that cry, Barbara and Jose will encounter an abnormal situation that will lead them to seek help in pseudo-science, Viviana's parents will seek explanations for the strange events that circulate Viviana's life.

An old hired killer is hiding in the interior of Bolivia, in the desert region of the Salar de Uyuni. You just committed your last murder. After months in isolation, he travels to the interior of Paraguay where he receives a good reward and heads to Asunción with the aim of meeting his daughter.

Two lifelong best friends, Juanda and Marce, summon their families and friends to tell them something that will completely change the evening.