O Negocio is a comedy-drama TV show that follows the lives of three women who enter the world of high-class prostitution in southeast Brazil. The show explores themes of female empowerment, friendship, and the challenges of running an independent business in a male-dominated industry.

After the death of his wife and his young daughter in a traffic accident for which he was responsible, Luna falls into a large pit of depression. Neither medication nor religion help him to keep going. Until one day, Luna has a dream that he receives as a revelation. In that dream, he sees himself driving a car and carrying a woman, Selva along with his son Beni. Luna takes it as a challenge and attempts to carry out his mission: to save the woman and the child from the dream.

A young actor faces success, unexpected love, and moral dilemmas that will alter his life forever during a therapy session.